Myosin Skeletal/Smooth Muscle Antibodies

Target Information

Myosin proteins are motor proteins critical for muscle contraction in both skeletal and smooth muscle. They convert chemical energy from ATP hydrolysis into mechanical energy, generating force and movement along actin filaments. In skeletal muscle, myosin molecules are part of the contractile apparatus, where they form thick filaments that interact with actin thin filaments to produce contraction. Myosin heavy chain (MyHC) isoforms are key determinants of muscle fiber types, contributing to the diversity in muscle function and specialization. Skeletal muscle fibers can express different MyHC isoforms, resulting in fibers with varying speed and endurance characteristics. Smooth muscle myosin, in contrast, is involved in the involuntary contractions of smooth muscle tissues found in the walls of hollow organs, such as the intestines and blood vessels. Smooth muscle myosin's regulatory mechanisms differ significantly from skeletal muscle, involving phosphorylation of the myosin light chain to initiate contraction.

Synonyms

A530084A17Rik; AAT4; AV071570; contractile protein; epididymis luminal protein 71; FAA4; HEL71; IId; IId/x; KIAA0866; MdMs; MHC2X/D; MHC-2X/D; MYH1; MYH11; myh11 {ECO:0000312; MYHa; MYHC; MyHC-2x; MyHC-2X/D; MyHC-IId/x; MYHC-IIX; myHC-IIx/d; MYHSA1; Myhs-f; Myhsf2; Myhs-f2; myosin heavy chain 1; Myosin heavy chain 11; myosin heavy chain 11, smooth muscle; myosin heavy chain 21; myosin heavy chain 2x; Myosin heavy chain IIx/d; myosin heavy chain isoform SMA; myosin heavy chain SMA; myosin heavy chain, skeletal muscle, adult 1; Myosin heavy chain, smooth muscle isoform; myosin, heavy chain 1, skeletal muscle, adult; myosin, heavy chain 11, smooth muscle; myosin, heavy polypeptide 1, skeletal muscle, adult; myosin, heavy polypeptide 11, smooth muscle; myosin-1; Myosin-11; RGD:3136}; SM1; SM2; SMHC; smMHC; smooth muscle myosin heavy chain; type 2X myosin heavy chain